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PepTracker®: PFL Home


The Protein Frequency Library

The Protein Frequency Library (PFL) was created at the end of 2009, and the paper explaining its creation is available at Establishment of a Protein Frequency Library and Its Application in the Reliable Identification of Specific Protein Interaction Partners.

Filtering Data

The PFL annotates the frequency of detection in co-immunoprecipitation and pulldown experiments for all proteins in the human proteome. It can provide a flexible and objective filter for discriminating between contaminants and specifically bound proteins and can be used to normalize data values and facilitate comparisons between data obtained in separate experiments. The PFL is a dynamic tool that can be filtered for specific experimental parameters to generate a customized library.

It will be continuously updated as data from each new experiment are added to the library, thereby p rogressively enhancing its utility. The application of the PFL to pulldown experiments is especially helpful in identifying either lower abundance or less tightly bound specific components of protein complexes that are otherwise lost among the large, nonspecific background

Encyclopedia of Proteome Dynamics

The Protein Frequency Library has a sister project called the Encyclopedia of Proteome dynamics. Here a large volume of proteomics data generated by the Lamond group and collaborators is hosted. The EPD is n Open Data, tool for sharing the results from our large-scale proteomics projects. It aims to integrate the information from multiple, complex data sets and quantitative studies in a single, user-friendly online resource.

The EPD is another tool which is part of the PepTracker suite, and though they serve different purposes both tools are related and can complement each other. To access the Encyclopedia of Proteome Dynamics and the data contained in it, simply click on its logo on your left.